Website
Module guide

Module LS4175 B

Module part: Mechanisms of Bacterial Pathogenicity (MedMicroBa)

Duration:
1 Semester
Turnus of offer:
each summer semester
Credit points:
3
Course of studies, specific field and terms:
  • Master Infection Biology 2018 (module part), Microbiology, 2nd semester
  • Master Infection Biology 2012 (module part), Microbiology, 2nd semester
Classes and lectures:
  • Mechanisms of Bacterial Pathogenicity (seminar, 2 SWS)
Workload:
  • 60 Hours private studies
  • 30 Hours in-classroom work
Contents of teaching:
  • Historical background: Milestones in the discovery of the factors involved in microbial virulence
  • Invasiveness, toxigenesis, colonization, specific adherence
  • Structure of bacterial cell membrane, cell wall and cell surface: Gram-positive and Gram-negative bacteria, mycobacteria, virulence factors
  • Structure and biosynthesis of lipopolysaccharides
  • Structure and biosynthesis of lipoarabinomannan
  • Structure, biosynthesis and functions of mycobacterial lipids
  • Recognition of microbial virulence factors by pattern recognition receptors
  • Recognition of lipids by immune cells, the role of CD1 presentation
  • Microbial toxins (e.g., leucocidin, hemolysin, botulinum toxin, diphtheria toxin, anthrax toxin, tetanus toxin, pertussis toxin, cholera enterotoxin, adenylate cyclase, Staphylococcus aureus enterotoxin, TSST, superantigen, shiga toxin, Escherichia coli LT toxin, ST toxin)
Qualification-goals/Competencies:
  • Competence in critical reading, discussing and presenting research articles
  • Student can explain structures and biosynthetic pathways of microbial constituents responsible for microbial virulence
  • Student can explain virulence mechanisms of pathogenic microorganisms
  • Student can evaluate the quality of experimental data
  • Student can present a research paper / topic in a seminar setting
  • Student can conduct literature researches using Pubmed
Grading through:
  • see Notes
Responsible for this module:
  • Siehe Hauptmodul
Teachers:
  • Prof. Dr. rer. nat. Otto Holst
  • Priv.-Doz. Dr. rer. nat. Sven Müller-Loennies
Literature:
  • n.n.: Provided research articles and own literature research
Language:
  • offered only in English
Notes:

Is module part of LS4175-KP06 Grading of the module part through - at least two oral presentations (20 min plus discussion) - regular in-class assessments - contribution to discussions - regular participation in seminars (85%)

Letzte Änderung:
17.7.2019