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Module LS4020 B

Module part LS4020B: NMR Spectroscopy (StrAnaNMR)

Duration:
1 Semester
Turnus of offer:
each winter semester
Credit points:
3
Course of studies, specific field and terms:
  • Master MLS 2018 (module part), structure biology, 1st semester
  • Master Infection Biology 2018 (module part), Interdisciplinary modules, 1st semester
  • Master Biophysics 2019 (module part), biophysics, 1st semester
  • Master CLS 2016 (module part), MML with specialization in Life Science, 3rd semester
  • Master MLS 2016 (module part), structure biology, 1st semester
  • Master Infection Biology 2012 (module part), Interdisciplinary modules, 1st semester
  • Master CLS 2010 (module part), computational life science / life sciences, 3rd semester
  • Master MLS 2009 (module part), structure biology, 1st semester
Classes and lectures:
  • NMR-Spectroscopy (lecture, 2 SWS)
Workload:
  • 30 Hours in-classroom work
  • 60 Hours private studies
Contents of teaching:
  • Lecture topics:
  • Assignment of NMR spectra
  • Description of the NOESY experiment using the vector model
  • Chemical Exchange and Transfer-NOEs
  • Multidimensional NMR spectroscopy
  • Assignment strategy for peptides
  • Introduction into the product operator formalism (POF)
  • Description of the COSY and of the HSQC experiment using POF
  • NMR experiments for the assignment of proteins
  • NMR structural analysis of proteins
  • Experiments to probe the motions of protein
Qualification-goals/Competencies:
  • Advanced techniques to assign and analyze NMR spectra
  • Understanding of NMR experiments based on the product operator formalism
  • Basic knowledge about NMR experiments to analyze structure and dynamics of proteins
Grading through:
  • see Notes
Responsible for this module:
  • Prof. Dr. rer. nat. Thomas Peters
Teachers:
  • Prof. Dr. rer. nat. Thomas Peters
  • PD Dr. rer. nat. Karsten Seeger
Literature:
  • James Keeler: Understanding NMR Spectroscopy - Wiley
  • :
  • Malcolm H. Levitt: Spin Dynamics - Basics of Nuclear Magnetic Resonance - Wiley-VCH
  • D. Neuhaus & M. P. Williamson: The Nuclear Overhauser Effect in Structural and Conformational Analysis - Wiley-VCH
  • Timothy Claridge: High-Resolution NMR Techniques in Organic Chemistry - Pergamon Press
  • : Current scientific literature
Language:
  • offered only in English
Notes:

This lecture is a part of modules: - LS4021-KP06 (former LS4020-IB) -> Prof. Hübner - LS4020-KP06 (former LS4020-MLS) and LS4020-KP12 -> Prof. Peters Exercises are integrated into the lectures. It is a compulsory module part for the Master MLS with a focus on structural biology.

Letzte Änderung:
17.7.2019