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Module guide

Module MA4661-KP08, MA4661

Genetic Epidemiology 2 (GenEpi2)

Duration:


1 Semester
Turnus of offer:


each summer semester
Credit points:


8
Course of studies, specific field and terms:
  • Master CLS 2023 (compulsory), MML with specialization in Genetic Statistics, 2nd semester
  • Bachelor CLS 2023 (optional suject), mathematics, 6th semester
  • Bachelor CLS 2016 (optional subject), mathematics, 6th semester
  • Master CLS 2016 (compulsory), MML with specialization in Genetic Statistics, 2nd semester
Classes and lectures:
  • Genetic Epidemiology 2 (practical course, 2 SWS)
  • Genetic Epidemiology 2 (lecture, 2 SWS)
  • Genetic Epidemiology 2 (exercise, 1 SWS)
Workload:
  • 135 Hours private studies
  • 30 Hours exam preparation
  • 75 Hours in-classroom work
Contents of teaching:
  • Classical methods of genetic epidemiology:
  • Designs for family studies
  • Model-based linkage analysis
  • Model-free linkage analysis
  • Linkage analysis for quantitative phenotypes
  • Family-based association tests
  • Current topics in genetic epidemiology, e.g.:
  • Association tests for rare variants
  • Association analysis for gene expression (eQTL, TWAS)
  • Polygenic risk scores
  • Mendelian randomization
  • Analysis of genetic data using specialized software packages (such as PLINK and MERLIN):
  • Genome-wide association studies
  • Family studies (linkage and association analyses)
Qualification-goals/Competencies:
  • Students will be able to name and describe the most important procedures for linkage and association analysis in family studies.
  • They know current analysis methods in genetic epidemiology.
  • They can perform elementary tests by hand and interpret the results.
  • They will be able to use software for more complex testing procedures and interpret the results.
Grading through:
  • Written or oral exam as announced by the examiner
Is requisite for:
Requires:
Responsible for this module:
  • Prof. Dr. rer. nat. Silke Szymczak
Teachers:
  • Prof. Dr. rer. nat. Silke Szymczak
  • MitarbeiterInnen des Instituts
Literature:
  • Ziegler A, König IR.: A statistical approach to genetic epidemiology. Concepts and applications. - 2010. ISBN: 978-3-527-32389-0
  • Recent review articles: (to be announced in lecture)
Language:
  • offered only in German
Notes:

Admission requirements for taking the module:
- None (The competencies of the modules listed under 'Requires' are needed for this module, but are not a formal prerequisite)

Admission requirements for participation in module examination(s):
- Examination prerequisites can be defined at the beginning of the semester. If preliminary work is defined, it must have been completed and positively evaluated before the first examination.

Module exam(s):
- MA4661-L1: Genetic Epidemiology 2, written exam (90 min) or oral exam (30 min), 100 % of module grade
- MA4661-L2: Practical Course Genetic Epidemiology 2, ungraded practical course, 0 % of module grade, must be passed

Letzte Änderung:
22.2.2022