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Module Guide before WS 2016/17

Modul LS4110 B

Part of the module LS4110B: Drug Design (WiFoDrug)

Duration:


1 Semester
Turnus of offer:


each summer semester
Credit points:


3
Course of studies, specific field and terms:
  • Master MLS 2018 (Module part of a compulsory module), cell biology, 2nd semester
  • Master MLS 2016 (Module part of a compulsory module), cell biology, 2nd semester
  • Master MLS 2009 (Module part of a compulsory module), structure biology, 2nd semester
Classes and lectures:
  • Drug Design (lecture, 2 SWS)
Workload:
  • 60 Hours private studies
  • 30 Hours in-classroom work
Contents of teaching:
  • Drug Discovery - An Overview
  • Target identification and validation
  • X-ray Crystallography in Drug Design
  • Structure-based drug design - Principles and Methods
  • Example of structure-based Drug Design - Tamiflu
  • NMR experiments in Drug Design
  • Chemical Synthesis of Drugs - Combinatorial Approaches
Qualification-goals/Competencies:
  • The students know basic strategies of Drug Design and are able to explain it.
  • They know the way from the target discovery to the drug and the techniques of rational Drug Design.
  • They know NMR and X-ray Crystallography as important tools for target monitoring and optimization and are able to explain it.
  • The students know the relationship between chemical structure and effect and the techniques for theoretical prognosis and experimental tests, particular x-ray crystallography and NMR-experiments.
  • The students understand concepts of synthesis and are able to assess their application in Drug Design.
  • The students know the borders of x-ray crystallography and NMR-experiments.
Grading through:
  • written exam
Responsible for this module:
  • Prof. Dr. rer. nat. Thomas Peters
Teachers:
  • Prof. Dr. rer. nat. Thomas Peters
  • Prof. Dr. Lars Redecke
Literature:
  • G. Klebe: Wirkstoffdesign - Spektrum-Verlag Heidelberg, 2009. ISBN 978-3-8274-2046-6
  • C.G. Wermuth, D. Aldous, P. Raboisson, D. Roynan: The Practice of Medicinal Chemistry, - 4th Ed., Academic Press, 2015
  • : Grundlagen- und Übersichtsartikel für beide Veranstaltungen
Language:
  • English, except in case of only German-speaking participants
Notes:

Part of the module LS4110

Letzte Änderung:
16.4.2021