Lübeck's research program "Infection and Inflammation" focuses on mechanisms underlying the course of infectious diseases and inflammatory phenomena in context of immune response including the exploration of molecular factors within humans and agents.
The approximately 80 contributing scientists of this program constitute the Center for Infectious Diseases and Inflammatory Medicine (ZIEL), where regular scientific exchange takes place as well as the share of a broad spectrum of infrastructure.
As inflammation is the steady reaction of cells, tissues and organs to potentially injurious agents, the goal is to reinstate a patient’s physiological integrity by eliminating or neutralising the noxae. The underlying procedures are essentially similar, with minor differences governed by the injurious agents, the sensors that recognise the danger, and the reaction arising at the location following the infection.
The contributing scientific groups concentrate primarily on understanding what takes place at various levels at the site of infection. For one, they compare the sequence of events that occur in the skin, lungs, intestines and tissues from physiological and pathophysiological perspectives and consequently analyse their connection to neurohormonal feedback mechanisms. Secondly, they also investigate organically similar cell groups to study inflammatory processes within and among individual cells in order to characterise paradigmatic triggering factors (such as microorganisms, parts of complement systems, autoantigens) and devise inhibition strategies.