Duration:
1 Semester | Turnus of offer:
each winter semester | Credit points:
3 |
Course of studies, specific field and terms: - Master MLS 2009 (Module part of a compulsory module), advanced curriculum MLS, 3rd semester
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Classes and lectures: - Progenitor Cells (seminar / exercises, 2 SWS)
| Workload: - 60 Hours private studies
- 30 Hours in-classroom work
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Contents of teaching: | - Types of stem cells: (i) embryonic stem cells (ESC), (ii) fetal stem cells (FSC), (iii) adult stem cells (aSC), (iv) tumor stem cells (CSC), (v) induced pluripotent stem cells (iPS)
- Definitions: stem cell/progenitor; features of neural (NSC), mesenchymal (MSC), hematopoietic (HSC) and tumor- (CSC) stem cells
- Characteristics and generation of iPS
- Characteristics of the stem cell niche
- non-neural and neural differentiation
- Neurogenesis: (i) neuro-epithelial cells, (ii) radial glia, (iii) types of neuronal and glial progenitors
- Factors regulating differentiation; factor-cocktails for the induction & differentiation of iPS
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Qualification-goals/Competencies: - They can explain the features of ESCs, FSCs, aSCs, CSCs and iPS
- They can list the characteristics and significance of NSCs, MSCs, HSCs and CSCs
- They can explain the production and significance of iPS
- They can explain the structure of the stem cell niche and its regulatory role
- They can detail protocols of directed differentiation (e.g. neural versus non-neural)
- Using neurogenesis as an example, they can tell how stem cells differentiate and what the terms cell fate decision and lateral inhibition indicate
- They can name factors which promote the stem cell character and which are used to allow the production of iPS cells or their differentiation, respectively
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Grading through: - Oral presentation and exercise with written report
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Responsible for this module: Teachers: - PD Dr. rer. nat. Christina Zechel
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Literature: - : Originalliteratur und Reviews zu den einzelnen Themenabschnitten
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Language: - English, except in case of only German-speaking participants
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Notes:Only for MLS. Prerequisites: Passed all modules of the 1. and 2. semester MSc |
Letzte Änderung: 16.4.2021 |
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